カタラーゼ産生促進剤、及びこれを含有する皮膚外用剤

Catalase production-promoting preparation and skin preparation for external use containing the same

Abstract

(57)【要約】 【課題】 有効且つ安定な皮膚線維芽細胞の カタラーゼ産生促進剤を得、さらに皮膚線維芽細胞の過 酸化水素消去能を向上させ、皮膚の老化症状の防止及び 改善に有効で、品質的にも安定な皮膚外用剤を提供す る。 【解決手段】 アマニンの極性溶媒による抽出物 を、スチレンポリマー製の吸着樹脂クロマトグラフィー にてエタノール・水混合溶媒により分画した際、50容 量%エタノール水溶液により溶出される画分をそのまま 又は濃縮,精製等を行い、或いはさらに担体に含有させ てカタラーゼ産生促進剤とする。また、前記カタラーゼ 産生促進剤の1種又は2種以上を外用剤基剤に含有させ て、皮膚外用剤とする。抽出溶媒としては、50容量% エタノール水溶液が好ましい。
PROBLEM TO BE SOLVED: To obtain an effective and stable promoting preparation for the production of a catalase of dermal fibroblasts, and further provide a skin preparation for external use enhancing the hydrogen peroxideeliminating capacity of the dermal fibroblasts, effective for the prevention and amelioration of ageing symptoms of the skin and stable in quality. SOLUTION: This catalase production-promoting preparation is obtained by using a fraction eluted by a 50 vol.% aqueous ethanol solution on fractionating an extract of a flaxseed with a polar solvent, with an adsorption resin chromatography made of a styrene polymer by using an ethanol-water mixed solvent, as it is or further performing concentration, purification, etc., or further incorporating it in a carrier. Further by incorporating 1 kind or >=2 kinds of the above catalase production-promoting preparation in a base preparation for an external agent, the skin preparation for external use is obtained. As the extracting solvent, 50 vol.% aqueous ethanol solution is preferable.

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