Silybin compound emulsion for intravenous injection and preparation method thereof

一种静脉注射用水飞蓟宾类化合物乳剂及其制备方法

Abstract

本发明涉及一种静脉注射用水飞蓟宾类化合物乳剂及其制备方法,配制1000ml的原料组成包括:水飞蓟宾类化合物0.08~8%,甘油三酯类化合物10~48%,乳化剂0.08~18%,水溶性或油溶性附加剂1~15%,其余为注射用水,该乳剂粒径的分布范围在0.1~1微米,平均粒径为0.2~0.4微米,其制备方法包括初乳制备、高压均质与灭菌等步骤;所述乳剂疗效显著、生物利用度高,并具有载药量高、缓释、被动肝靶向、毒副作用低等特点。
The invention relates to a silibinin compound emulsion used for intravenous injection and a preparation method. Components for preparing raw material of 1000 ml comprise 0.08 percent to 8 percent silibinin compound, 10 percent to 48 percent triglyceride compound, 0.08 percent to 18 percent emulsifier, 1 percent to 15 percent water-soluble or oil-soluble addition agent and the reminder which is injection water. The distribution range of particle size of the emulsion is ranged from 0.1 micron to 1 micron, and the average particle size is ranged from 0.2 micron to 0.4 micron. The preparation method comprises steps which are colostrum preparation, high pressure homogenization, sterilization, and the like; the emulsion has the advantages of dramatic efficacy, high bioavailability, high drug loading, sustained release, passive liver targeting, low toxic side effect, and the like.

Claims

Description

Topics

Download Full PDF Version (Non-Commercial Use)

Patent Citations (0)

    Publication numberPublication dateAssigneeTitle

NO-Patent Citations (0)

    Title

Cited By (3)

    Publication numberPublication dateAssigneeTitle
    CN-102614121-AAugust 01, 2012上海天氏利医药科技有限公司一种水飞蓟宾注射液的组合物及其制备方法
    CN-102614121-BDecember 11, 2013上海天氏利医药科技有限公司Silibinin injection composition and preparation process
    US-9248115-B2February 02, 2016Madaus GmbhSilibinin component for the treatment of hepatitis