Silybin compound emulsion for intravenous injection and preparation method thereof



The invention relates to a silibinin compound emulsion used for intravenous injection and a preparation method. Components for preparing raw material of 1000 ml comprise 0.08 percent to 8 percent silibinin compound, 10 percent to 48 percent triglyceride compound, 0.08 percent to 18 percent emulsifier, 1 percent to 15 percent water-soluble or oil-soluble addition agent and the reminder which is injection water. The distribution range of particle size of the emulsion is ranged from 0.1 micron to 1 micron, and the average particle size is ranged from 0.2 micron to 0.4 micron. The preparation method comprises steps which are colostrum preparation, high pressure homogenization, sterilization, and the like; the emulsion has the advantages of dramatic efficacy, high bioavailability, high drug loading, sustained release, passive liver targeting, low toxic side effect, and the like.




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Cited By (3)

    Publication numberPublication dateAssigneeTitle
    CN-102614121-AAugust 01, 2012上海天氏利医药科技有限公司一种水飞蓟宾注射液的组合物及其制备方法
    CN-102614121-BDecember 11, 2013上海天氏利医药科技有限公司Silibinin injection composition and preparation process
    US-9248115-B2February 02, 2016Madaus GmbhSilibinin component for the treatment of hepatitis